Publication on high-titre circulating tissue transglutaminase-2 antibodies
High-titre circulating tissue transglutaminase-2 antibodies predict small bowel villous atrophy, but decision cut-off limits must be locally validated
1 Jan 2013 | By Beltran, L. et al.
Numerous studies suggest that high levels of circulating IgA tissue transglutaminase (TTG2) antibodies predict coeliac disease with high specificity. Accordingly, it has been suggested that duodenal biopsy may not be required routinely for diagnostic confirmation where quantitative serology identifies the presence of high antibody titres. However, defining a cut-off TTG2 threshold is problematic, as the multiple available assay methods are not harmonized. Clin Exp Immunol. 2014 May;176(2):190-8